Hybrid Polyion Complexes for MRI


⠀⠀⠀⠀Hybrid polyion complexes (HPICs) are formed by adding metal ions to a double-hydrophilic block copolymer leading to highly monodisperse polymer based nano-objects.  HPICs provide an opportunity to combine attributes of the hydrophilic polymer, among them compatibility with biological systems, with properties of the inorganic ions.  Working closely with collaborators at the Université de Toulouse, we are developing HPIC’s as innovative magnetic resonance imaging (MRI) contrast agents.

“Ionic Flash NanoPrecipitation (iFNP) for the facile, one-step synthesis of inorganic–organic hybrid nanoparticles in water”  N. M. Pinkerton, L. Behar, K. Hadri, B. Amouroux, C. Mingotaud, D. R. Talham, S. Chassaing, and J.-D. Marty.  Nanoscale, 2017, 9, 1403-1408 

“Assembly of double-hydrophilic block copolymers triggered by gadolinium ions: new colloidal MRI contrast agents”  Frangville, Camille; Li, Yichen; Billotey, Claire; Talham, Daniel; Taleb, Jacqueline; Roux, Patrick; Marty, Jean-Daniel; Mingotaud, Christophe  Nano Lett.  2016, 16, 4069-4073

“Hyperbranched polymer mediated size-controlled synthesis of gadolinium phosphate nanoparticles: colloidal properties and particle size-dependence on MRI relaxivity”  Camille Frangville, Maylis Gallois, Yichen Li, Hong Hanh Nguyen, Nancy Lauth-de Viguerie, Daniel R. Talham,* Christophe Mingotaud and Jean-Daniel Marty*  Nanoscale  2016, 8, 4252-4259